Synthesis of 2,4-Disubstituted Imidazoles via Nucleophilic Catalysis
نویسندگان
چکیده
منابع مشابه
Regioselective synthesis of 1,4-disubstituted imidazoles.
A short and efficient synthesis of 1,4-disubstituted imidazoles has been developed which provides the desired products with complete regioselectivity. This protocol allows preparation of compounds which are challenging to prepare by current literature methods in a regioselective fashion, a sterically and electronically diverse range of N-substituents being accessible. The sequence involves an u...
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The [3+2] cycloaddition between various nitriles and sodium azide proceeds smoothly in the presence of zeolite and sulfated Zircona as effective catalyst and in the water and DMF/MeOH, to give the corresponding arylaminotetrazoles in good to high yields. The reaction most probably precedes through the in situ formation of a catalyst azide species, followed by a successive [3+2] cycloaddition wi...
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ژورنال
عنوان ژورنال: Synlett
سال: 2020
ISSN: 0936-5214,1437-2096
DOI: 10.1055/s-0039-1690832